Professor Mark Cook

  • Room: Level: 04 Room: 404
  • Building: Clinical Sciences Block
  • Campus: St Vincents Hospital


Director of the Graeme Clark Institute, and Sir John Eccles Chair of Medicine, Department of Medicine, University of Melbourne. I also direct the Department of Neurology, St. Vincent's Hospital, with both clinical and administrative responsibilities. I spend 1 day weekly in clinical practice. My specific scientific and clinical expertise has created a unique opportunity to take a leadership role in developing translational research to the treatment of intractable epilepsy. My aim has been to develop a basic and translational research program focused on epilepsy and other neurological diseases to drive the development of collaborative clinical research infrastructure that crosses disciplines. My objectives have included the development of new and innovative imaging processes, basic cell biology in epilepsy and the neurophysiology of epilepsy. Over the last 5 years we have made significant inroads into developing therapeutic electrical stimulation strategies for the treatment of epilepsy, of proven effect in animal models and now being explored in humans. In addition, large groups of physical scientists have been brought into human and animal research, and further developing these links is a key aim. This has been achieved not only through the main work of my laboratory but also through increased collaboration with other University of Melbourne based research groups, supported by Australian Research Council (ARC) and National and Health Medical Research Council (NHMRC) funding. Insights and therapies developed through my research have been translated into practice now, and by utilizing a diverse group of collaborators to enhance the translation of developing research outcomes into health practice, leveraging existing but isolated national resources to create an internationally competitive, clinically- focused research infrastructure.

Recent publications

  1. Nurse E, John S, Freestone D, Oxley T, Ung H, Berkovic S, O'Brien T, Cook M, Grayden D. Consistency of Long-Term Subdural Electrocorticography in Humans. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. IEEE - Institute of Electrical and Electronic Engineers. 2018, Vol. 65, Issue 2. DOI: 10.1109/TBME.2017.2768442
  2. Li MCH, Cook M. Deep brain stimulation for drug-resistant epilepsy. Epilepsia. Blackwell Science. 2018, Vol. 59, Issue 2. DOI: 10.1111/epi.13964
  3. Freestone D, Karoly P, Cook M. A forward-looking review of seizure prediction. CURRENT OPINION IN NEUROLOGY. Lippincott Williams & Wilkins. 2017, Vol. 30, Issue 2. DOI: 10.1097/WCO.0000000000000429
  4. Goldenholz DM, Strashny A, Cook M, Moss R, Theodore WH. A multi-dataset time-reversal approach to clinical trial placebo response and the relationship to natural variability in epilepsy. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY. WB Saunders Co. 2017, Vol. 53. DOI: 10.1016/j.seizure.2017.10.016
  5. Karoly P, Nurse E, Freestone D, Ung H, Cook M, Boston R. Bursts of seizures in long-term recordings of human focal epilepsy. EPILEPSIA. Blackwell Science. 2017, Vol. 58, Issue 3. DOI: 10.1111/epi.13636
  6. Seneviratne U, Hepworth G, Cook M, D'Souza W. Can EEG Differentiate Among Syndromes in Genetic Generalized Epilepsy?. JOURNAL OF CLINICAL NEUROPHYSIOLOGY. Lippincott Williams & Wilkins. 2017, Vol. 34, Issue 3. DOI: 10.1097/WNP.0000000000000358
  7. Baldassano SN, Brinkmann BH, Ung H, Blevins T, Conrad EC, Leyde K, Cook M, Khambhati AN, Wagenaar JB, Worrell GA, Litt B. Crowdsourcing seizure detection: algorithm development and validation on human implanted device recordings. BRAIN. Oxford University Press. 2017, Vol. 140. DOI: 10.1093/brain/awx098
  8. Viana JNM, Vickers JC, Cook M, Gilbert F. Currents of memory: recent progress, translational challenges, and ethical considerations in fornix deep brain stimulation trials for Alzheimer's disease. NEUROBIOLOGY OF AGING. Elsevier Science. 2017, Vol. 56. DOI: 10.1016/j.neurobiolaging.2017.03.001
  9. Chen Y, Gu Q, Yue Z, Crook J, Moulton SE, Cook M, Wallace G. Development of drug-loaded polymer microcapsules for treatment of epilepsy. BIOMATERIALS SCIENCE. R S C Publications. 2017, Vol. 5, Issue 10. DOI: 10.1039/c7bm00623c
  10. Goldenholz DM, Goldenholz SR, Moss R, French J, Lowenstein D, Kuzniecky R, Haut S, Cristofaro S, Detyniecki K, Hixson J, Karoly P, Cook M, Strashny A, Theodore WH, Pieper C. Does accounting for seizure frequency variability increase clinical trial power?. EPILEPSY RESEARCH. Elsevier Science. 2017, Vol. 137. DOI: 10.1016/j.eplepsyres.2017.07.013
  11. Seneviratne U, Boston R, Cook M, D'Souza W. EEG correlates of seizure freedom in genetic generalized epilepsies. NEUROLOGY-CLINICAL PRACTICE. Lippincott Williams & Wilkins. 2017, Vol. 7, Issue 1. DOI: 10.1212/CPJ.0000000000000323
  12. Seneviratne U, Cook M, D'Souza W. Electroencephalography in the diagnosis of genetic generalized epilepsy syndromes. Frontiers in Neurology. Frontiers Research Foundation. 2017, Vol. 8, Issue SEP. DOI: 10.3389/fneur.2017.00499
  13. Seneviratne U, Cook M, D'Souza W. Electroencephalography in the Diagnosis of Genetic Generalized Epilepsy Syndromes. FRONTIERS IN NEUROLOGY. Frontiers Research Foundation. 2017, Vol. 8. DOI: 10.3389/fneur2017.00499
  14. Gilbert F, Cook M, O Brien T, Illes J. Embodiment and Estrangement: Results from First-in-Human “Intelligent BCI” Trial. Science and Engineering Ethics. Springer. 2017. DOI: 10.1007/s11948-017-0001-5
  15. Kiral-Kornek I, Roy S, Nurse E, Mashford B, Karoly P, Carroll T, Payne D, Saha S, Baldassano S, O'Brien T, Grayden D, Cook M, Freestone D, Harrer S. Epileptic Seizure Prediction Using Big Data and Deep Learning: Toward a Mobile System. EBioMedicine. Elsevier. 2017. DOI: 10.1016/j.ebiom.2017.11.032

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile