Neurodevelopment and disease modelling

Stem cell and bioengineering technologies are creating innovative in-vitro models of brain function to better understand disease of the human brain.

Run under the Stem Cells and Disease Models Laboratory at the University’s Centre for Neural Engineering, our research focuses on autism spectrum disorders and Friedreich’s Ataxia in particular.

The lab aims to understand how to direct human pluripotent stem cell fate to specific lineages of the nervous system, to develop cellular models of neurogenesis and diseases, and the application of models in regenerative therapies.

Multi-electrode arrays are used to study neuronal networks, graphene scaffolds and cerebral organoids for 3D in vitro brain modelling. These model systems are applied to interrogate disease states.