Professor Mark Cook

  • Room: Level: 04 Room: 404
  • Building: Clinical Sciences Block
  • Campus: St Vincents Hospital


Director of the Graeme Clark Institute, and Sir John Eccles Chair of Medicine, Department of Medicine, University of Melbourne. I also direct the Department of Neurology, St. Vincent's Hospital, with both clinical and administrative responsibilities. I spend 1 day weekly in clinical practice. My specific scientific and clinical expertise has created a unique opportunity to take a leadership role in developing translational research to the treatment of intractable epilepsy. My aim has been to develop a basic and translational research program focused on epilepsy and other neurological diseases to drive the development of collaborative clinical research infrastructure that crosses disciplines. My objectives have included the development of new and innovative imaging processes, basic cell biology in epilepsy and the neurophysiology of epilepsy. Over the last 5 years we have made significant inroads into developing therapeutic electrical stimulation strategies for the treatment of epilepsy, of proven effect in animal models and now being explored in humans. In addition, large groups of physical scientists have been brought into human and animal research, and further developing these links is a key aim. This has been achieved not only through the main work of my laboratory but also through increased collaboration with other University of Melbourne based research groups, supported by Australian Research Council (ARC) and National and Health Medical Research Council (NHMRC) funding. Insights and therapies developed through my research have been translated into practice now, and by utilizing a diverse group of collaborators to enhance the translation of developing research outcomes into health practice, leveraging existing but isolated national resources to create an internationally competitive, clinically- focused research infrastructure.

Recent publications

  1. Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez M, Johannsen VA, Cook M, Crowston J, Hill A, Duce J, Bush A, Trounce I. Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity. MOLECULAR NEUROBIOLOGY. Humana Press. 2019, Vol. 56, Issue 8. DOI: 10.1007/s12035-018-1460-7
  2. Allebone J, Kanaan R, Maller J, O'Brien T, Mullen S, Cook M, Adams S, Vogrin S, Vaughan D, Connelly A, Kwan P, Berkovic S, D'Souza W, Jackson G, Velakoulis D, Wilson S. Bilateral volume reduction in posterior hippocampus in psychosis of epilepsy. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. BMJ Publishing Group. 2019, Vol. 90, Issue 6. DOI: 10.1136/jnnp-2018-319396
  3. Gilbert F, Cook M, O'Brien T, Illes J. Embodiment and Estrangement: Results from a First-in-Human "Intelligent BCI" Trial. SCIENCE AND ENGINEERING ETHICS. Springer. 2019, Vol. 25, Issue 1. DOI: 10.1007/s11948-017-0001-5
  4. Seneviratne U, Karoly P, Freestone D, Cook M, Boston R. Methods for the Detection of Seizure Bursts in Epilepsy. FRONTIERS IN NEUROLOGY. Frontiers Research Foundation. 2019, Vol. 10. DOI: 10.3389/fneur.2019.00156
  5. Tan M, Boston R, Cook M, D'Souza W. Risk factors for injury in a community-treated cohort of patients with epilepsy in Australia. 68th Annual Meeting of the American-Academy-of-Neurology (AAN). Blackwell Science. 2019, Vol. 60, Issue 3. DOI: 10.1111/epi.14659
  6. Imms P, Clemente A, Cook M, D'Souza W, Wilson PH, Jones DK, Caeyenberghs K. The structural connectome in traumatic brain injury: A meta-analysis of graph metrics. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. Pergamon-Elsevier Science. 2019, Vol. 99. DOI: 10.1016/j.neubiorev.2019.01.002
  7. Cook M. "Truths and roses have thorns about them" - Henry David Thoreau. EPILEPSIA. Blackwell Science. 2018, Vol. 59, Issue 6. DOI: 10.1111/epi.14433
  8. Van Tienderen GS, Berthel M, Yue Z, Cook M, Liu X, Beirne S, Wallace G. Advanced fabrication approaches to controlled delivery systems for epilepsy treatment. EXPERT OPINION ON DRUG DELIVERY. Informa Healthcare. 2018, Vol. 15, Issue 9. DOI: 10.1080/17425247.2018.1517745
  9. Karoly P, Goldenholz DM, Cook M. Are the days of counting seizures numbered?. CURRENT OPINION IN NEUROLOGY. Lippincott Williams & Wilkins. 2018, Vol. 31, Issue 2. DOI: 10.1097/WCO.0000000000000533
  10. Ahmadizadeh S, Karoly P, Nesic D, Grayden D, Cook M, Soudry D, Freestone D. Bifurcation analysis of two coupled Jansen-Rit neural mass models. PLOS ONE. Public Library of Science. 2018, Vol. 13, Issue 3. DOI: 10.1371/journal.pone.0192842
  11. Seneviratne U, Boston R, Cook M, D'Souza W. Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies. FRONTIERS IN NEUROLOGY. Frontiers Research Foundation. 2018, Vol. 9. DOI: 10.3389/fneur.2018.00036
  12. Neal A, Carne R, Odell M, Ballek D, D'Souza W, Cook M. Characteristics of motor vehicle crashes associated with seizure Car crash semiology. NEUROLOGY. Lippincott Williams & Wilkins. 2018, Vol. 91, Issue 12. DOI: 10.1212/WNL.0000000000006208
  13. Karoly P, Goldenholz DM, Freestone D, Moss RE, Grayden D, Theodore WH, Cook M. Circadian and circaseptan rhythms in human epilepsy: a retrospective cohort study. LANCET NEUROLOGY. The Lancet Publishing Group. 2018, Vol. 17, Issue 11. DOI: 10.1016/S1474-4422(18)30274-6
  14. Tatum WO, Rubboli G, Kaplan PW, Mirsatari SM, Radhakrishnan K, Gloss D, Caboclo LO, Drislane FW, Koutroumanidis M, Schomer DL, Trenite DK-N, Cook M, Beniczky S. Clinical utility of EEG in diagnosing and monitoring epilepsy in adults. CLINICAL NEUROPHYSIOLOGY. Elsevier Science Ireland. 2018, Vol. 129, Issue 5. DOI: 10.1016/j.clinph.2018.01.019
  15. Goldenholz DM, Moss R, Jost DA, Crone NE, Krauss G, Picard R, Caborni C, Cavazos JE, Hixson J, Loddenkemper T, Salazar TD, Lubbers L, Harte-Hargrove LC, Whittemore V, Duun-Henriksen J, Dolan E, Kasturia N, Oberemk M, Cook M, Lehmkuhle M, Sperling MR, Shafer PO. Common data elements for epilepsy mobile health systems. EPILEPSIA. Blackwell Science. 2018, Vol. 59, Issue 5. DOI: 10.1111/epi.14066

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile