Professor Mark Cook

  • Room: Level: 04 Room: 404
  • Building: Clinical Sciences Block
  • Campus: St Vincents Hospital


Director of the Graeme Clark Institute, and Sir John Eccles Chair of Medicine, Department of Medicine, University of Melbourne. I also direct the Department of Neurology, St. Vincent's Hospital, with both clinical and administrative responsibilities. I spend 1 day weekly in clinical practice. My specific scientific and clinical expertise has created a unique opportunity to take a leadership role in developing translational research to the treatment of intractable epilepsy. My aim has been to develop a basic and translational research program focused on epilepsy and other neurological diseases to drive the development of collaborative clinical research infrastructure that crosses disciplines. My objectives have included the development of new and innovative imaging processes, basic cell biology in epilepsy and the neurophysiology of epilepsy. Over the last 5 years we have made significant inroads into developing therapeutic electrical stimulation strategies for the treatment of epilepsy, of proven effect in animal models and now being explored in humans. In addition, large groups of physical scientists have been brought into human and animal research, and further developing these links is a key aim. This has been achieved not only through the main work of my laboratory but also through increased collaboration with other University of Melbourne based research groups, supported by Australian Research Council (ARC) and National and Health Medical Research Council (NHMRC) funding. Insights and therapies developed through my research have been translated into practice now, and by utilizing a diverse group of collaborators to enhance the translation of developing research outcomes into health practice, leveraging existing but isolated national resources to create an internationally competitive, clinically- focused research infrastructure.

Recent publications

  1. Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez M, Johannsen VA, Cook M, Crowston J, Hill A, Duce J, Bush A, Trounce I. Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity. MOLECULAR NEUROBIOLOGY. Humana Press. 2019, Vol. 56, Issue 8. DOI: 10.1007/s12035-018-1460-7
  2. Cimdins K, Waugh HS, Chrysostomou V, Lopez Sanchez M, Johanssen VA, Cook M, Crowston J, Hill A, Duce J, Bush A, Trounce I. Amyloid Precursor Protein Mediates Neuronal Protection from Rotenone Toxicity (vol 56, pg 5471, 2019). MOLECULAR NEUROBIOLOGY. Humana Press. 2019, Vol. 56, Issue 10. DOI: 10.1007/s12035-019-01726-2
  3. Allebone J, Kanaan R, Maller J, O'Brien T, Mullen S, Cook M, Adams S, Vogrin S, Vaughan D, Connelly A, Kwan P, Berkovic S, D'Souza W, Jackson G, Velakoulis D, Wilson S. Bilateral volume reduction in posterior hippocampus in psychosis of epilepsy. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. BMJ Publishing Group. 2019, Vol. 90, Issue 6. DOI: 10.1136/jnnp-2018-319396
  4. Baldassano S, Zhao X, Brinkmann B, Kremen V, Bernabei J, Cook M, Denison T, Worrell G, Litt B. Cloud computing for seizure detection in implanted neural devices. JOURNAL OF NEURAL ENGINEERING. Institute of Physics Publishing. 2019, Vol. 16, Issue 2. DOI: 10.1088/1741-2552/aaf92e
  5. Cook B, Cook M. Does my posterior look big in this?—Bayesian solutions to seizure counting problems. Epilepsia Open. 2019, Vol. 4, Issue 2. DOI: 10.1002/epi4.12328
  6. Gilbert F, Cook M, O'Brien T, Illes J. Embodiment and Estrangement: Results from a First-in-Human "Intelligent BCI" Trial. SCIENCE AND ENGINEERING ETHICS. Springer. 2019, Vol. 25, Issue 1. DOI: 10.1007/s11948-017-0001-5
  7. Woldman W, Cook M, Terry JR. Evolving dynamic networks: An underlying mechanism of drug resistance in epilepsy?. EPILEPSY & BEHAVIOR. Academic Press - Elsevier Science. 2019, Vol. 94. DOI: 10.1016/j.yebeh.2019.03.003
  8. Plummer C, Vogrin S, Woods WP, Murphy M, Cook M, Liley D. Interictal and ictal source localization for epilepsy surgery using high-density EEG with MEG: a prospective long-term study. BRAIN. Oxford University Press. 2019, Vol. 142, Issue 4. DOI: 10.1093/brain/awz015
  9. Seneviratne U, Karoly P, Freestone D, Cook M, Boston R. Methods for the Detection of Seizure Bursts in Epilepsy. FRONTIERS IN NEUROLOGY. Frontiers Research Foundation. 2019, Vol. 10. DOI: 10.3389/fneur.2019.00156
  10. Tan M, Boston R, Cook M, D'Souza W. Risk factors for injury in a community-treated cohort of patients with epilepsy in Australia. 68th Annual Meeting of the American-Academy-of-Neurology (AAN). Blackwell Science. 2019, Vol. 60, Issue 3. DOI: 10.1111/epi.14659
  11. Edward K-L, Cook M, Stephenson J, Giandinoto J-A. The impact of brief lifestyle self-management education for the control of seizures.. Br J Nurs. 2019, Vol. 28, Issue 6. DOI: 10.12968/bjon.2019.28.6.348
  12. Imms P, Clemente A, Cook M, D'Souza W, Wilson PH, Jones DK, Caeyenberghs K. The structural connectome in traumatic brain injury: A meta-analysis of graph metrics. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. Pergamon-Elsevier Science. 2019, Vol. 99. DOI: 10.1016/j.neubiorev.2019.01.002
  13. Karoly P, Romero J, Cook M, Freestone D, Goldenholz DM. When can we trust responders? Serious concerns when using 50% response rate to assess clinical trials. EPILEPSIA. Blackwell Science. 2019, Vol. 60, Issue 9. DOI: 10.1111/epi.16321
  14. Cook M. "Truths and roses have thorns about them" - Henry David Thoreau. EPILEPSIA. Blackwell Science. 2018, Vol. 59, Issue 6. DOI: 10.1111/epi.14433
  15. Van Tienderen GS, Berthel M, Yue Z, Cook M, Liu X, Beirne S, Wallace G. Advanced fabrication approaches to controlled delivery systems for epilepsy treatment. EXPERT OPINION ON DRUG DELIVERY. Informa Healthcare. 2018, Vol. 15, Issue 9. DOI: 10.1080/17425247.2018.1517745

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile