Professor Mark Cook

  • Room: Level: 04 Room: 404
  • Building: Clinical Sciences Block
  • Campus: St Vincents Hospital


Director of the Graeme Clark Institute, and Sir John Eccles Chair of Medicine, Department of Medicine, University of Melbourne. I also direct the Department of Neurology, St. Vincent's Hospital, with both clinical and administrative responsibilities. I spend 1 day weekly in clinical practice. My specific scientific and clinical expertise has created a unique opportunity to take a leadership role in developing translational research to the treatment of intractable epilepsy. My aim has been to develop a basic and translational research program focused on epilepsy and other neurological diseases to drive the development of collaborative clinical research infrastructure that crosses disciplines. My objectives have included the development of new and innovative imaging processes, basic cell biology in epilepsy and the neurophysiology of epilepsy. Over the last 5 years we have made significant inroads into developing therapeutic electrical stimulation strategies for the treatment of epilepsy, of proven effect in animal models and now being explored in humans. In addition, large groups of physical scientists have been brought into human and animal research, and further developing these links is a key aim. This has been achieved not only through the main work of my laboratory but also through increased collaboration with other University of Melbourne based research groups, supported by Australian Research Council (ARC) and National and Health Medical Research Council (NHMRC) funding. Insights and therapies developed through my research have been translated into practice now, and by utilizing a diverse group of collaborators to enhance the translation of developing research outcomes into health practice, leveraging existing but isolated national resources to create an internationally competitive, clinically- focused research infrastructure.

Recent publications

  1. Karoly P, Goldenholz DM, Cook M. Are the days of counting seizures numbered?. CURRENT OPINION IN NEUROLOGY. Lippincott Williams & Wilkins. 2018, Vol. 31, Issue 2. DOI: 10.1097/WCO.0000000000000533
  2. Ahmadizadeh S, Karoly PJ, Nesic D, Grayden D, Cook M, Soudry D, Freestone D. Bifurcation analysis of two coupled Jansen-Rit neural mass models. PLOS ONE. Public Library of Science. 2018, Vol. 13, Issue 3. DOI: 10.1371/journal.pone.0192842
  3. Seneviratne U, Boston RC, Cook M, D'Souza W. Characteristics of Epileptiform Discharge Duration and Interdischarge Interval in Genetic Generalized Epilepsies. FRONTIERS IN NEUROLOGY. Frontiers Research Foundation. 2018, Vol. 9. DOI: 10.3389/fneur.2018.00036
  4. Tatum WO, Rubboli G, Kaplan PW, Mirsatari SM, Radhakrishnan K, Gloss D, Caboclo LO, Drislane FW, Koutroumanidis M, Schomer DL, Trenite DK-N, Cook M, Beniczky S. Clinical utility of EEG in diagnosing and monitoring epilepsy in adults. CLINICAL NEUROPHYSIOLOGY. Elsevier Science Ireland. 2018, Vol. 129, Issue 5. DOI: 10.1016/j.clinph.2018.01.019
  5. Goldenholz DM, Moss R, Jost DA, Crone NE, Krauss G, Picard R, Caborni C, Cavazos JE, Hixson J, Loddenkemper T, Salazar TD, Lubbers L, Harte-Hargrove LC, Whittemore V, Duun-Henriksen J, Dolan E, Kasturia N, Oberemk M, Cook M, Lehmkuhle M, Sperling MR, Shafer PO. Common data elements for epilepsy mobile health systems. EPILEPSIA. Blackwell Science. 2018, Vol. 59, Issue 5. DOI: 10.1111/epi.14066
  6. Nurse E, John S, Freestone D, Oxley T, Ung H, Berkovic S, O'Brien T, Cook M, Grayden D. Consistency of Long-Term Subdural Electrocorticography in Humans. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING. IEEE - Institute of Electrical and Electronic Engineers. 2018, Vol. 65, Issue 2. DOI: 10.1109/TBME.2017.2768442
  7. Li MCH, Cook M. Deep brain stimulation for drug-resistant epilepsy. EPILEPSIA. Blackwell Science. 2018, Vol. 59, Issue 2. DOI: 10.1111/epi.13964
  8. Neal A, D'Souza W, Hepworth G, Lawn N, Cook M, Nikpour A. Efficacy and tolerability of adjuvant lacosamide: The role of clinical characteristics and mechanisms of action of concomitant AEDs. EPILEPSY & BEHAVIOR. Academic Press - Elsevier Science. 2018, Vol. 80. DOI: 10.1016/j.yebeh.2017.11.027
  9. Kiral-Kornek I, Roy S, Nurse E, Mashford B, Karoly P, Carroll T, Payne D, Saha S, Baldassano S, O'Brien T, Grayden D, Cook M, Freestone D, Harrer S. Epileptic Seizure Prediction Using Big Data and Deep Learning: Toward a Mobile System. EBIOMEDICINE. Elsevier. 2018, Vol. 27. DOI: 10.1016/j.ebiom.2017.11.032
  10. Goldenholz DM, Goldenholz SR, Moss R, French J, Lowenstein D, Kuzniecky R, Haut S, Cristofaro S, Detyniecki K, Hixson J, Karoly P, Cook M, Strashny A, Theodore WH. Is seizure frequency variance a predictable quantity?. ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY. John Wiley & Sons. 2018, Vol. 5, Issue 2. DOI: 10.1002/acn3.519
  11. Payne DE, Karoly PJ, Freestone D, Boston R, D'Souza W, Nurse E, Kuhlmann L, Cook M, Grayden D. Postictal suppression and seizure durations: A patient-specific, long-term iEEG analysis. EPILEPSIA. Blackwell Science. 2018, Vol. 59, Issue 5. DOI: 10.1111/epi.14065
  12. Gilbert F, O'Brien T, Cook M. The Effects of Closed-Loop Brain Implants on Autonomy and Deliberation What are the Risks of Being Kept in the Loop?. CAMBRIDGE QUARTERLY OF HEALTHCARE ETHICS. Cambridge University Press. 2018, Vol. 27, Issue 2. DOI: 10.1017/S0963180117000640
  13. Bourke J, Quigley A, Duchi S, O'Connell CD, Crook JM, Wallace GG, Cook M, Kapsa R. Three-dimensional neural cultures produce networks that mimic native brain activity. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE. John Wiley & Sons. 2018, Vol. 12, Issue 2. DOI: 10.1002/term.2508
  14. Freestone D, Karoly P, Cook M. A forward-looking review of seizure prediction. CURRENT OPINION IN NEUROLOGY. Lippincott Williams & Wilkins. 2017, Vol. 30, Issue 2. DOI: 10.1097/WCO.0000000000000429
  15. Goldenholz DM, Strashny A, Cook M, Moss R, Theodore WH. A multi-dataset time-reversal approach to clinical trial placebo response and the relationship to natural variability in epilepsy. SEIZURE-EUROPEAN JOURNAL OF EPILEPSY. WB Saunders Co. 2017, Vol. 53. DOI: 10.1016/j.seizure.2017.10.016

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile