Associate Professor Leigh Johnston

  • Room: Level: 01 Room: 29
  • Building: Kenneth Myer Bld
  • Campus: Parkville

Research interests

  • Magnetic Resonance Imaging
  • Medical Imaging
  • Signal Processing

Biography

Associate Professor Leigh Johnston is a member of the Department of Biomedical Engineering within the School of Chemical and Biomedical Engineering. Her primary research focus is medical imaging, in particular Magnetic Resonance Imaging. Leigh holds an honorary appointment at the Florey Institute of Neuroscience and Mental Health, where she is Head of the Animal MRI facility. She is also a member of the Melbourne Brain Centre Imaging Unit, with research programs utilising the Siemens 7T and Siemens PET/CT clinical systems on the Parkville campus. Leigh’s expertise in MRI spans from acquisition sequences to image analysis and applications. Prior to her appointment at The University of Melbourne, Leigh was a postdoctoral researcher at the Howard Florey Institute (Melbourne), York University (Canada), and the Université catholique de Louvain (Belgium).

Recent publications

  1. Syeda W, Blunck Y, Kolbe S, Cleary J, Johnston L. A continuum of T*2 components: Flexible fast fraction mapping in sodium MRI. Magnetic Resonance in Medicine. John Wiley & Sons. 2019. DOI: 10.1002/mrm.27659
  2. Kottaram A, Johnston L, Cocchi L, Ganella EP, Everall I, Pantelis C, Kotagiri R, Zalesky A. Brain network dynamics in schizophrenia: Reduced dynamism of the default mode network. Human Brain Mapping. Wiley-Liss. 2019. DOI: 10.1002/hbm.24519
  3. Tubi MA, Lutkenhoff E, Blanco MB, McArthur D, Villablanca P, Ellingson B, Diaz-Arrastia R, Van Ness P, Real C, Shrestha V, Engel J, Vespa PM, Agoston D, Au A, Bell MJ, Bleck T, Branch C, Buitrago Blanco M, Bullock R, Burrows BT, Claassen J, Clarke R, Cloyd J, Coles L, Crawford K, Duncan D, Foreman B, Galanopoulou A, Gilmore E, Olli G, Harris N, Hartings J, Lawrence H, Hunn M, Jette N, Johnston L, Jones N, Kanner A, Monti M, Morokoff A, Moshe S, Mowrey W, O'Brien T, O'Phelan K, Pitkanen A, Raman R, Robertson C, Rosenthal E, Shultz S, Snutch T, Staba R, Toga A, Van Horn J, Vespa P, Willyerd F, Zimmermann L. Early seizures and temporal lobe trauma predict post-traumatic epilepsy: A longitudinal study. Neurobiology of Disease. Academic Press. 2019, Vol. 123. DOI: 10.1016/j.nbd.2018.05.014
  4. Immonen R, Smith G, Brady R, Wright D, Johnston L, Harris NG, Manninen E, Salo R, Branch C, Duncan D, Cabeen R, Ndode-Ekane XE, Gomez CS, Casillas-Espinosa PM, Ali I, Shultz S, Andrade P, Puhakka N, Staba RJ, O'Brien T, Toga AW, PitkÄnen A, GrÖhn O. Harmonization of pipeline for preclinical multicenter MRI biomarker discovery in a rat model of post-traumatic epileptogenesis. Epilepsy Research. Elsevier Science. 2019, Vol. 150. DOI: 10.1016/j.eplepsyres.2019.01.001
  5. Immonen R, Harris NG, Wright D, Johnston L, Manninen E, Smith G, Paydar A, Branch C, Grohn O. Imaging biomarkers of epileptogenecity after traumatic brain injury – Preclinical frontiers. Neurobiology of Disease. Academic Press. 2019, Vol. 123. DOI: 10.1016/j.nbd.2018.10.008
  6. Vespa PM, Shrestha V, Abend N, Agoston D, Au A, Bell MJ, Bleck TP, Blanco MB, Claassen J, Diaz-Arrastia R, Duncan D, Ellingson B, Foreman B, Gilmore EJ, Hirsch L, Hunn M, Kamnaksh A, McArthur D, Morokoff A, O'Brien T, O'Phelan K, Robertson CL, Rosenthal E, Staba R, Toga A, Willyerd FA, Zimmermann L, Yam E, Martinez S, Real C, Engel J, Bleck Thomas P, Branch C, Buitrago Blanco M, Bullock R, Burrows BT, Clarke R, Cloyd J, Coles L, Crawford K, Ellingson B, Galanopoulou A, Gilmore E, Grohn O, Harris N, Hartings J, Lawrence H, Jette N, Johnston L, Jones N, Kanner A, Monti M, Moshe S, Mowrey W, O'Brien T, Pitkanen A, Raman R, Robertson C, Shultz S, Snutch T, Van Horn J, Vespa P, Willyerd F. The epilepsy bioinformatics study for anti-epileptogenic therapy (EpiBioS4Rx) clinical biomarker: Study design and protocol. Neurobiology of Disease. Academic Press. 2019, Vol. 123. DOI: 10.1016/j.nbd.2018.07.025
  7. Blunck Y, Moffat B, Kolbe S, Ordidge R, Cleary J, Johnston L. Zero-gradient-excitation ramped hybrid encoding (zGRF-RHE) sodium MRI. Magnetic Resonance in Medicine. John Wiley & Sons. 2019, Vol. 81, Issue 2. DOI: 10.1002/mrm.27484
  8. Blunck Y, Josan S, Taqdees SW, Moffat B, Ordidge R, Cleary J, Johnston L. 3D-multi-echo radial imaging of Na-23 (3D-MERINA) for time-efficient multi-parameter tissue compartment mapping. MAGNETIC RESONANCE IN MEDICINE. John Wiley & Sons. 2018, Vol. 79, Issue 4. DOI: 10.1002/mrm.26848
  9. Kottaram A, Johnston L, Ganella E, Pantelis C, Kotagiri R, Zalesky A. Spatio-temporal dynamics of resting-state brain networks improve single-subject prediction of schizophrenia diagnosis. HUMAN BRAIN MAPPING. Wiley-Liss. 2018, Vol. 39, Issue 9. DOI: 10.1002/hbm.24202
  10. Taqdees SW, Ng A, Wright DK, Tolcos M, Johnston L. ANALYSIS OF ADC MODEL ROBUSTNESS IN DIFFUSION-WEIGHTED MRI. 2017 IEEE 14TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2017). IEEE. 2017. DOI: 10.1109/ISBI.2017.7950676
  11. Shishegar R, Joshi AA, Tolcos M, Walker DW, Johnston L. AUTOMATIC SEGMENTATION OF FETAL BRAIN USING DIFFUSION-WEIGHTED IMAGING CUES. 2017 IEEE 14TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2017). IEEE. 2017. DOI: 10.1109/ISBI.2017.7950640
  12. Wright D, Johnston L, Kershaw J, Ordidge R, O'Brien T, Shultz S. Changes in Apparent Fiber Density and Track-Weighted Imaging Metrics in White Matter following Experimental Traumatic Brain Injury. JOURNAL OF NEUROTRAUMA. Mary Ann Liebert Publishers. 2017, Vol. 34, Issue 13. DOI: 10.1089/neu.2016.4730
  13. Sharma P, Wright D, Johnston L, Powell K, Wlodek M, Shultz S, O'Brien T, Gilby K. Differences in white matter structure between seizure prone (FAST) and seizure resistant (SLOW) rat strains. NEUROBIOLOGY OF DISEASE. Academic Press. 2017, Vol. 104. DOI: 10.1016/j.nbd.2017.04.022
  14. Korte J, Layton KJ, Tahayori B, Farrell P, Moore SM, Johnston L. NMR spectroscopy using Rabi modulated continuous wave excitation. BIOMEDICAL SIGNAL PROCESSING AND CONTROL. Elsevier Science. 2017, Vol. 33. DOI: 10.1016/j.bspc.2016.10.006
  15. Wright D, Liu S, Van Der Poel C, McDonald S, Brady R, Taylor L, Yang L, Gardner AJ, Ordidge R, O'Brien T, Johnston L, Shultz S. Traumatic Brain Injury Results in Cellular, Structural and Functional Changes Resembling Motor Neuron Disease. CEREBRAL CORTEX. Oxford University Press. 2017, Vol. 27, Issue 9. DOI: 10.1093/cercor/bhw254

View a full list of publications on the University of Melbourne’s ‘Find An Expert’ profile